From Molecules to Memory -
Expression Mechanisms and Behavioural Correlates of Long-Term Potentiation (LTP)

Chapter 1

1.1 Historical overview of memory research

1.2 Long Term Potentiation

1.2.1 Early findings

1.2.2 Unresolved questions

1.3 Genetic techniques transform neuroscience

1.4 The Hippocampus

1.4.1 Anatomy

1.4.1 Spatial memory

1.5 The Amygdala

1.5.1 Anatomy

1.5.2 Fear conditioning

1.6 Outline of thesis

Chapter 2

2.1 GluR-A-/- mice tested on standard spatial tasks

2.2 T-maze

2.3 Visual discrimination in the T-maze

2.4 Y-maze

2.5 Watermaze

2.6 Post-watermaze T-maze

2.7 Paddling pool

2.8 Discussion

Chapter 3

3.1 Hippocampal lesions of GluR-A-/- mice

3.2 T-Maze

3.3 Y-maze

3.4 Watermaze

3.5 Discussion

Chapter 4

4.1 GluR-A-/- mice tested on non-spatial tasks

4.2 Strain comparison of C57s and 129sv mice

4.3 Hippocampal lesions on DRL

4.3 DRL-10 (Batch 1)

4.4 DRL-15 (Batch 1)

4.5 DRL-15 (Batch 2)

4.6 DRL-10 (Batch 2)

4.7 Discussion

Chapter 5

5.1 Amygdala LTP recordings in GluR-A-/- mice

5.2 Methods

5.3 Results

5.3.1 Stimulation of LA

5.3.2 Stimulation of BLA

5.3.3 Blocking with AP5

5.4 Discussion

Chapter 6

6.1 Fear conditioning in GluR-A-/- mice

6.2 FPS Methods

6.3 Results

6.4 Neophobia

6.5 Discussion